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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 12268Generated: October 25, 2026

1,3-Diethyl 2-oxopropanedioate → Diethyl 2-[2-(2-ethylaminopyrimidin-4-yl)-2-oxo-ethyl]-2-hydroxymalonate

https://huagongshe.com/reaction/12268

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-Diethyl 2-oxopropanedioateHCID 69105—
Reactant1-(2-(Ethylamino)pyrimidin-4-yl)ethanoneHCID 68452125—
ProductDiethyl 2-[2-(2-ethylaminopyrimidin-4-yl)-2-oxo-ethyl]-2-hydroxymalonateHCID 68452836—

Reaction Conditions

Temperature110 °C

Reaction Steps

A mixture consisting of 1.9 g of 1-(2-ethylaminopyrimidin-4-yl)ethanone and 1.86 ml of diethyl ketomalonate is heated at 110° C. for 18 hours. The mixture is purified by column chromatography (silica gel, mobile phase:methylene chloride:methanol=98:2).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07727989B2
Source datasetuspto-grants-2010_06
ORD IDord-0d9dbd0ceb884aa9952e31fab8bb9478
Source noteuspto-grants-2010_06