Tetrahydrofuran → 1-(2-Chloro-4-fluoro-phenyl)-2-(4-hydroxy-phenyl)-3-methyl-5-piperidin-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

HRID 1227010Notes

Reaction equation

[C:1]([Si:2]([CH3:3])([CH3:4])[O:6][c:7]1[cH:8][cH:9][c:10](-[c:13]2[c:14]([CH3:37])[c:15]3[c:20]([n:21]2-[c:22]2[c:23]([Cl:29])[cH:24][c:25]([F:28])[cH:26][cH:27]2)[CH2:19][CH2:18][N:17]([N:30]2[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]2)[C:16]3=[O:36])[cH:11][cH:12]1)([CH3:5])([CH3:38])[CH3:39].[CH2:41]([N+:42]([CH2:43][CH2:44][CH2:45][CH3:46])([CH2:47][CH2:48][CH2:49][CH3:50])[CH2:51][CH2:52][CH2:53][CH3:54])[CH2:55][CH2:56][CH3:57].[CH2:58]1[O:59][CH2:60][CH2:61][CH2:62]1.[F-:40]>>[OH:6][c:7]1[cH:8][cH:9][c:10](-[c:13]2[c:14]([CH3:37])[c:15]3[c:20]([n:21]2-[c:22]2[c:23]([Cl:29])[cH:24][c:25]([F:28])[cH:26][cH:27]2)[CH2:19][CH2:18][N:17]([N:30]2[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]2)[C:16]3=[O:36])[cH:11][cH:12]1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 16028Tetrabutylammonium

HCID 28179Fluoride Ion

HCID 668656722-[4-(tert-Butyldimethylsilanyloxy)phenyl]-1-(2-chloro-4-fluorophenyl)-3-methyl-5-piperidin-1-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

Product 1

HCID 166661661-(2-Chloro-4-fluoro-phenyl)-2-(4-hydroxy-phenyl)-3-methyl-5-piperidin-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

Sources & evidence

ORD record: ord-5bb3cfc9813c47a5b5c1fb0212bde078
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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