Tetrahydrofuran → 2-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-5-(1-cyclobutylvinyl)-thiazolo[5,4-b]pyridine

HRID 1227047Notes

Reaction equation

HRID 1227047 reaction equation
[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[KH:34].[O:1]1[CH:2]([c:7]2[cH:8][c:9]([F:33])[c:10](-[c:13]3[s:14][c:15]4[n:16][c:17]([C:22]([CH2:23][Si:25]([CH3:26])([CH3:27])[CH3:28])([OH:24])[CH:29]5[CH2:30][CH2:31][CH2:32]5)[cH:18][cH:19][c:20]4[n:21]3)[cH:11][cH:12]2)[O:3][CH2:4][CH2:5][CH2:6]1>>[O:1]1[CH:2]([c:7]2[cH:8][c:9]([F:33])[c:10](-[c:13]3[s:14][c:15]4[n:16][c:17]([C:22](=[CH2:23])[CH:29]5[CH2:30][CH2:31][CH2:32]5)[cH:18][cH:19][c:20]4[n:21]3)[cH:11][cH:12]2)[O:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 671116841-(2-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)thiazolo[5,4-b]pyridin-5-yl)-1-cyclobutyl-2-(trimethylsilyl)ethanolHCID 178506623HCID 178506623, compound

Product 1

HCID 671120572-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-5-(1-cyclobutylvinyl)-thiazolo[5,4-b]pyridine

Sources & evidence

ORD record
ord-1773fd0f05f249c2aee28003ca34d02d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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