Methanol → tert-Butyl 5-bromo-1-oxo-1,3-dihydro-2H-isoindole-2-carboxylate

HRID 1228074Notes

Reaction equation

HRID 1228074 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[C:7](=[O:11])[NH:6][CH2:5]2.[C:12]([CH3:13])([CH3:14])([CH3:15])[O:16][C:17]([O:18][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:19].[CH3:24][OH:25].[O:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1>>[Br:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[C:7](=[O:11])[N:6]([C:17]([O:16][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:18])[CH2:5]2

Participants

5

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 10219638Carbonic acid, bis(1,1-dimethylethyl) esterHCID 226071195-bromo-2,3-dihydro-1H-isoindol-1-one

Product 1

HCID 23158154tert-Butyl 5-bromo-1-oxo-1,3-dihydro-2H-isoindole-2-carboxylate

Sources & evidence

ORD record
ord-4f67ec3b6ff344ebb9542351cda561b6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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