Chloride → 3-Benzyloxycarbonylamino-3-(1,1-difluoro-2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[BH4-:33].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]([C:14]([CH:15]=[CH2:16])([F:17])[F:18])([NH:19][C:20](=[O:21])[O:22][CH2:23][c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[CH2:11][CH2:12][CH2:13]1.[C:35](=[O:36])([OH:37])[O-:38].[CH3:42][OH:43].[CH:44]([Cl:45])([Cl:46])[Cl:47].[Cl-:41].[Na+:34].[Na+:39].[Na+:40].[O-:30][O+:31]=[O:32]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]([C:14]([CH2:15][OH:30])([F:17])[F:18])([NH:19][C:20](=[O:21])[O:22][CH2:23][c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[CH2:11][CH2:12][CH2:13]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-703122ebd3314a19a8a492670afc7e17
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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