2-Methylspiro[isoindoline-3,4'-piperidine]-1-one → 2-Methyl-1'-(3-(2-(trifluoromethyl)phenyl)propanoyl)spiro[isoindoline-1,4'-piperidin]-3-one
Reaction equation
[CH3:16][N:17]1[C:18]2([c:19]3[cH:20][cH:21][cH:22][cH:23][c:24]3[C:25]1=[O:26])[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]2.[F:1][C:2]([c:3]1[c:4]([CH2:9][CH2:10][C:11](=[O:12])[OH:13])[cH:5][cH:6][cH:7][cH:8]1)([F:14])[F:15]>>[F:1][C:2]([c:3]1[c:4]([CH2:9][CH2:10][C:11](=[O:13])[N:29]2[CH2:28][CH2:27][C:18]3([N:17]([CH3:16])[C:25](=[O:26])[c:24]4[c:19]3[cH:20][cH:21][cH:22][cH:23]4)[CH2:31][CH2:30]2)[cH:5][cH:6][cH:7][cH:8]1)([F:14])[F:15]Participants
3
Sources & evidence
- ORD record
- ord-cb4e55091b4848e899105dd58a363e17
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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