6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-phenyl)amide → 4-(1H-Benzimidazol-2-yl)-6-chloro-2H-pyridazin-3-one

HRID 12283Notes

Reaction equation

HRID 12283 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([C:11]1[C:12](=[O:18])[NH:13][N:14]=[C:15]([Cl:17])[CH:16]=1)=O>C(O)(=O)C>[NH:8]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[N:1]=[C:9]1[C:11]1[C:12](=[O:18])[NH:13][N:14]=[C:15]([Cl:17])[CH:16]=1

Participants

3

Reactant 1

HCID 866116096-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-phenyl)amide

Product 1

HCID 1359787814-(1H-Benzimidazol-2-yl)-6-chloro-2H-pyridazin-3-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 26.4 g of 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-aminophenyl)amide in 500 ml of acetic acid is stirred at 110° C. for 2.5 hours and then the solvent is distilled off. The crude product obtained in this way is employed without further purification.

Workup

  1. distillationthe solvent is distilled off

Sources & evidence

ORD record
ord-0a5a35357a4242119c12cf0fec91f87f
Source dataset
uspto-grants-2010_06
Patent number
US07727989B2

Reaction notes

Loading…