Bicarbonate Ion → Tert-butyl 1-(4-chloro-3-fluorobenzyl)-4-piperidinylcarbamate

HRID 1228478Notes

Reaction equation

HRID 1228478 reaction equation
[C:25]([O:26][BH-:27]([O:28][C:29](=[O:30])[CH3:31])[O:32][C:33](=[O:34])[CH3:35])(=[O:36])[CH3:37].[C:39](=[O:40])([O-:41])[OH:42].[Cl:1][c:2]1[c:3]([F:10])[cH:4][c:5]([CH:6]=[O:7])[cH:8][cH:9]1.[NH:11]1[CH2:12][CH2:13][CH:14]([NH:17][C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:15][CH2:16]1.[Na+:38].[Na+:43].[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1>>[Cl:1][c:2]1[c:3]([F:10])[cH:4][c:5]([CH2:6][N:11]2[CH2:12][CH2:13][CH:14]([NH:17][C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:15][CH2:16]2)[cH:8][cH:9]1

Participants

7

Reactant 6

HCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 8028TetrahydrofuranHCID 7238334-(N-Boc-amino)piperidineHCID 2724942TriacetoxyborohydrideHCID 27249854-Chloro-3-Fluorobenzaldehyde

Product 1

HCID 68886889Tert-butyl 1-(4-chloro-3-fluorobenzyl)-4-piperidinylcarbamate

Sources & evidence

ORD record
ord-ab370812367e4eceb3b05941d17d73e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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