Dichloromethane → tert-Butyl 4-({2-(3-{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethylpropyl)-6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-1-oxo-1,2-dihydroisoquinolin-4-yl}sulfinyl)piperidine-1-carboxylate
Reaction equation
[C:12]([CH3:13])([CH3:14])([CH3:15])[Si:16]([O:17][CH2:18][C:19]([CH2:20][n:21]1[c:22](=[O:59])[c:23]2[cH:24][cH:25][c:26](-[c:45]3[c:46]([CH3:58])[c:47]([F:57])[cH:48][c:49]([C:51]([NH:52][CH:53]4[CH2:54][CH2:55]4)=[O:56])[cH:50]3)[cH:27][c:28]2[c:29]([S:31][CH:32]2[CH2:33][CH2:34][N:35]([C:38](=[O:39])[O:40][C:41]([CH3:42])([CH3:43])[CH3:44])[CH2:36][CH2:37]2)[cH:30]1)([CH3:60])[CH3:61])([CH3:62])[CH3:63].[Cl:64][CH2:65][Cl:66].[OH:1][O:2][C:3]([c:4]1[cH:5][c:6]([Cl:7])[cH:8][cH:9][cH:10]1)=[O:11]>>[O:1]=[S:31]([c:29]1[c:28]2[c:23]([c:22](=[O:59])[n:21]([CH2:20][C:19]([CH2:18][O:17][Si:16]([C:12]([CH3:13])([CH3:14])[CH3:15])([CH3:62])[CH3:63])([CH3:60])[CH3:61])[cH:30]1)[cH:24][cH:25][c:26](-[c:45]1[c:46]([CH3:58])[c:47]([F:57])[cH:48][c:49]([C:51]([NH:52][CH:53]3[CH2:54][CH2:55]3)=[O:56])[cH:50]1)[cH:27]2)[CH:32]1[CH2:33][CH2:34][N:35]([C:38](=[O:39])[O:40][C:41]([CH3:42])([CH3:43])[CH3:44])[CH2:36][CH2:37]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-14ae6170158c45948fcbca1f04555046
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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