Methylamine → HCID 68680816, compound

Participants

Reaction Steps

200 mg of methoxy-5-{6-oxo-1-(2-trimethylsilanylethoxymethyl)-5-[1-(2-trimethylsilanylethoxymethyl)-1H-benzimidazol-2-yl]-1,6-dihydropyridazin-3-yl}-2-(2-trimethylsilanylethoxymethoxy)benzaldehyde are dissolved in 4.5 ml of methanol and methylamine (0.146 ml of a THF solution), and 18.4 mg of sodium cyanoborohydride are added, followed by 17 mg of acetic acid. After stirring at room temperature for 16 hours, the volatile components are distilled off and the crude product is employed without further purification for the next reaction.

Provenance & Evidence