Water → 3-((6-Chloro-3-cyanoimidazo[1,2-b]pyridazin-8-yl)(4-methoxybenzyl)amino)-N-methyl-N-(1-methylpyrrolidin-3-yl)benzamide

HRID 1230082Notes

Reaction equation

HRID 1230082 reaction equation
[CH3:32][NH:33][CH:34]1[CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]1.[Cl:1][c:2]1[cH:3][c:4]([N:13]([c:14]2[cH:15][c:16]([C:17](=[O:18])[OH:19])[cH:20][cH:21][cH:22]2)[CH2:23][c:24]2[cH:25][cH:26][c:27]([O:30][CH3:31])[cH:28][cH:29]2)[c:5]2[n:6]([n:7]1)[c:8]([C:11]#[N:12])[cH:9][n:10]2.[O:41]=[CH:42][N:43]([CH3:44])[CH3:45].[OH2:40]>>[Cl:1][c:2]1[cH:3][c:4]([N:13]([c:14]2[cH:15][c:16]([C:17](=[O:18])[N:33]([CH3:32])[CH:34]3[CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]3)[cH:20][cH:21][cH:22]2)[CH2:23][c:24]2[cH:25][cH:26][c:27]([O:30][CH3:31])[cH:28][cH:29]2)[c:5]2[n:6]([n:7]1)[c:8]([C:11]#[N:12])[cH:9][n:10]2

Participants

5

Reactant 4

HCID 962WaterHCID 6228DimethylformamideHCID 2758520N,1-dimethylpyrrolidin-3-amineHCID 593140063-((6-Chloro-3-cyanoimidazo[1,2-b]pyridazin-8-yl)(4-methoxybenzyl)amino)benzoic acid

Product 1

HCID 593140333-((6-Chloro-3-cyanoimidazo[1,2-b]pyridazin-8-yl)(4-methoxybenzyl)amino)-N-methyl-N-(1-methylpyrrolidin-3-yl)benzamide

Sources & evidence

ORD record
ord-1fbc8b190f40460e8042164fec021baf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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