Dichloromethane → 3-[5-(3,5-Difluorobenzamido)-2-methylphenyl]-6-(4-methylpiperazin-1-yl)-3,4-dihydroquinazolin-4-one
Reaction equation
[CH2:45]([Cl:46])[Cl:47].[CH3:38][CH2:39][N:40]([CH2:41][CH3:42])[CH2:43][CH3:44].[F:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[Cl:7])[cH:8][c:9]([F:11])[cH:10]1.[NH2:12][c:13]1[cH:14][cH:15][c:16]([CH3:37])[c:17](-[n:19]2[cH:20][n:21][c:22]3[cH:23][cH:24][c:25]([N:30]4[CH2:31][CH2:32][N:33]([CH3:36])[CH2:34][CH2:35]4)[cH:26][c:27]3[c:28]2=[O:29])[cH:18]1>>[F:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[NH:12][c:13]2[cH:14][cH:15][c:16]([CH3:37])[c:17](-[n:19]3[cH:20][n:21][c:22]4[cH:23][cH:24][c:25]([N:30]5[CH2:31][CH2:32][N:33]([CH3:36])[CH2:34][CH2:35]5)[cH:26][c:27]4[c:28]3=[O:29])[cH:18]2)[cH:8][c:9]([F:11])[cH:10]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-27f08cd78d7f43b5a40be3fb400e993a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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