Chloroform → 3-Bromo-8-(4-morpholinyl)pyrido[2,3-d]pyridazine

HRID 1231009Notes

Reaction equation

[Br:1][c:2]1[cH:3][c:4]2[c:5]([c:6](=[O:10])[nH:7][n:8][cH:9]2)[n:11][cH:12]1.[CH2:18]1[CH2:19][O:20][CH2:21][CH2:22][NH:23]1.[Cl:24][CH:25]([Cl:26])[Cl:27].[P:13]([Cl:14])([Cl:15])([Cl:16])=[O:17]>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([N:23]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)[n:7][n:8][cH:9]2)[n:11][cH:12]1

Participants

Reactant 4

HCID 6212Chloroform

HCID 8083Morpholine

HCID 24813Phosphorus oxychloride

HCID 684549573-Bromopyrido[2,3-d]pyridazin-8(7H)-one

Product 1

HCID 684552693-Bromo-8-(4-morpholinyl)pyrido[2,3-d]pyridazine

Sources & evidence

ORD record: ord-f2a85e497d0b4228a65bc42ec9042a3b
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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