4-Methylmorpholine → Methyl 2-[4-[[3-chloro-4-(trifluoromethoxy)phenyl]carbamoyl]-3-methyl-2-oxopiperazin-1-yl]-5-(8-hydroxy-6-azaspiro[2.5]octan-6-yl)-5-oxopentanoate
Reaction equation
[CH3:1][O:2][C:3]([CH:4]([CH2:5][CH2:6][C:7](=[O:8])[N:9]1[CH2:10][CH:11]([OH:17])[C:12]2([CH2:13][CH2:14]2)[CH2:15][CH2:16]1)[N:18]1[C:19](=[O:25])[CH:20]([CH3:24])[NH:21][CH2:22][CH2:23]1)=[O:26].[CH3:27][N:28]1[CH2:29][CH2:30][O:31][CH2:32][CH2:33]1.[Cl:34][c:35]1[c:36]([O:44][C:45]([F:46])([F:47])[F:48])[cH:37][cH:38][c:39]([N:41]=[C:42]=[O:43])[cH:40]1>>[CH3:1][O:2][C:3]([CH:4]([CH2:5][CH2:6][C:7](=[O:8])[N:9]1[CH2:10][CH:11]([OH:17])[C:12]2([CH2:13][CH2:14]2)[CH2:15][CH2:16]1)[N:18]1[C:19](=[O:25])[CH:20]([CH3:24])[N:21]([C:42]([NH:41][c:39]2[cH:38][cH:37][c:36]([O:44][C:45]([F:46])([F:47])[F:48])[c:35]([Cl:34])[cH:40]2)=[O:43])[CH2:22][CH2:23]1)=[O:26]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-f02c0db7334d45b8910863556712faa5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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