Tetrahydrofuran → 3-[3-(4-Pyrrolidin-1-ylmethyl-phenyl)-cyclobutylmethoxymethyl]-benzonitrile

HRID 1231174Notes

Reaction equation

HRID 1231174 reaction equation
[Br:19][CH2:20][c:21]1[cH:22][c:23]([C:24]#[N:25])[cH:26][cH:27][cH:28]1.[N:1]1([CH2:6][c:7]2[cH:8][cH:9][c:10]([CH:13]3[CH2:14][CH:15]([CH2:17][OH:18])[CH2:16]3)[cH:11][cH:12]2)[CH2:2][CH2:3][CH2:4][CH2:5]1.[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1>>[N:1]1([CH2:6][c:7]2[cH:8][cH:9][c:10]([CH:13]3[CH2:14][CH:15]([CH2:17][O:18][CH2:20][c:21]4[cH:22][c:23]([C:24]#[N:25])[cH:26][cH:27][cH:28]4)[CH2:16]3)[cH:11][cH:12]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 97249Benzonitrile, 3-(bromomethyl)-HCID 21934866[3-(4-Pyrrolidin-1-ylmethyl-phenyl)-cyclobutyl]-methanol

Product 1

HCID 219348423-[3-(4-Pyrrolidin-1-ylmethyl-phenyl)-cyclobutylmethoxymethyl]-benzonitrile

Sources & evidence

ORD record
ord-55ed7755122c4dc7b25bfc56417e52fe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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