Hydrochloric Acid → Ethyl 5-chloro-6-(piperazin-1-YL)nicotinate

HRID 1231589Notes

Reaction equation

HRID 1231589 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([C:21](=[O:22])[O:23][CH2:24][CH3:25])[cH:18][c:19]2[Cl:20])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[ClH:26].[O:27]1[CH2:28][CH2:29][O:30][CH2:31][CH2:32]1.[O:33]1[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1>>[NH:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([C:21](=[O:22])[O:23][CH2:24][CH3:25])[cH:18][c:19]2[Cl:20])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-Dioxane2×HCID 59168365Ethyl 6-[1-(tert-butoxycarbonyl)piperazin-4-yl]-5-chloronicotinate

Product 1

HCID 22028944Ethyl 5-chloro-6-(piperazin-1-YL)nicotinate

Sources & evidence

ORD record
ord-34181b2f20214f2a9c72deab100e1371
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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