2-chloro-N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-4-pyrimidineamine → N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-N2-[2,3-dihydro-2-(methoxycarbonyl)benzofuran-5-yl]-2,4-primidinediamine

HRID 1231972Notes

Reaction equation

HRID 1231972 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([F:21])[c:6]([NH:8][c:9]2[cH:10][c:11]([Cl:20])[c:12]([O:15][C:16]([F:17])([F:18])[F:19])[cH:13][cH:14]2)[n:7]1.[NH2:22][c:23]1[cH:24][cH:25][c:26]2[c:27]([cH:35]1)[CH2:28][CH:29]([C:31](=[O:32])[O:33][CH3:34])[O:30]2>>[c:2]1([NH:22][c:23]2[cH:24][cH:25][c:26]3[c:27]([cH:35]2)[CH2:28][CH:29]([C:31](=[O:32])[O:33][CH3:34])[O:30]3)[n:3][cH:4][c:5]([F:21])[c:6]([NH:8][c:9]2[cH:10][c:11]([Cl:20])[c:12]([O:15][C:16]([F:17])([F:18])[F:19])[cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 220604622-chloro-N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-4-pyrimidineamineHCID 22060823Methyl 5-amino-2,3-dihydrobenzofuran-2-carboxylate

Product 1

HCID 10174439N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-N2-[2,3-dihydro-2-(methoxycarbonyl)benzofuran-5-yl]-2,4-primidinediamine

Sources & evidence

ORD record
ord-5a0f2d4f4ed94d33b252ffaf636af661
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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