Bicarbonate Ion → [4-(1-Chloropyrido[3,4-d]pyridazin-4-yl)-2-methylpiperazin-1-yl]-phenylmethanone

HRID 1231989Notes

Reaction equation

HRID 1231989 reaction equation
[C:19]([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)(=[O:26])[Cl:27].[C:35](=[O:36])([OH:37])[O-:38].[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[Cl:1][c:2]1[c:3]2[c:4]([c:5]([N:8]3[CH2:9][CH:10]([CH3:14])[NH:11][CH2:12][CH2:13]3)[n:6][n:7]1)[cH:15][n:16][cH:17][cH:18]2.[Cl:42][CH2:43][Cl:44].[Na+:39].[Na+:41].[OH-:40]>>[Cl:1][c:2]1[c:3]2[c:4]([c:5]([N:8]3[CH2:9][CH:10]([CH3:14])[N:11]([C:19]([c:20]4[cH:21][cH:22][cH:23][cH:24][cH:25]4)=[O:26])[CH2:12][CH2:13]3)[n:6][n:7]1)[cH:15][n:16][cH:17][cH:18]2

Participants

8

Reactant 7

HCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 961HydroxideHCID 6344DichloromethaneHCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 765851571-Chloro-4-(3-methylpiperazin-1-yl)pyrido[3,4-d]pyridazine

Product 1

HCID 76585155[4-(1-Chloropyrido[3,4-d]pyridazin-4-yl)-2-methylpiperazin-1-yl]-phenylmethanone

Sources & evidence

ORD record
ord-256df700d3034f4b85df6fac1c9f9d0c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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