Dichloromethane → Methyl 3-(1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)cyclopropylamino)propanoate

HRID 1232014Notes

Reaction equation

HRID 1232014 reaction equation
[C:30]([CH:31]=[CH2:32])(=[O:33])[O:34][CH3:35].[Cl:36][CH2:37][Cl:38].[F:1][c:2]1[cH:3][c:4]([C:26]2([NH2:29])[CH2:27][CH2:28]2)[cH:5][cH:6][c:7]1-[c:8]1[s:9][c:10]2[n:11][c:12]([C:17]3([c:20]4[cH:21][cH:22][cH:23][cH:24][cH:25]4)[CH2:18][CH2:19]3)[cH:13][cH:14][c:15]2[n:16]1>>[F:1][c:2]1[cH:3][c:4]([C:26]2([NH:29][CH2:32][CH2:31][C:30](=[O:33])[O:34][CH3:35])[CH2:27][CH2:28]2)[cH:5][cH:6][c:7]1-[c:8]1[s:9][c:10]2[n:11][c:12]([C:17]3([c:20]4[cH:21][cH:22][cH:23][cH:24][cH:25]4)[CH2:18][CH2:19]3)[cH:13][cH:14][c:15]2[n:16]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 7294Methyl AcrylateHCID 446011061-(3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)cyclopropanamine

Product 1

HCID 68635658Methyl 3-(1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)cyclopropylamino)propanoate

Sources & evidence

ORD record
ord-8104cbb0302d497988d71876d3f18679
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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