Dichloromethane → 5-cyclopropyl-3-methoxy-1-(4-methoxybenzyl)-4-(piperazin-1-yl)-1H-pyrazolo[3,4-b]pyridine

HRID 1232185Notes

Reaction equation

HRID 1232185 reaction equation
[CH:1]1([c:4]2[c:5]([N:24]3[CH2:25][CH2:26][N:27]([C:30]([O:31][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:36])[CH2:28][CH2:29]3)[c:6]3[c:7]([n:8][cH:9]2)[n:10]([CH2:15][c:16]2[cH:17][cH:18][c:19]([O:22][CH3:23])[cH:20][cH:21]2)[n:11][c:12]3[O:13][CH3:14])[CH2:2][CH2:3]1.[Cl:44][CH2:45][Cl:46].[F:37][C:38]([F:39])([F:40])[C:41]([OH:42])=[O:43]>>[CH:1]1([c:4]2[c:5]([N:24]3[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]3)[c:6]3[c:7]([n:8][cH:9]2)[n:10]([CH2:15][c:16]2[cH:17][cH:18][c:19]([O:22][CH3:23])[cH:20][cH:21]2)[n:11][c:12]3[O:13][CH3:14])[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 68757913tert-butyl 4-(5-cyclopropyl-3-methoxy-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)piperazine-1-carboxylate

Product 1

HCID 687593505-cyclopropyl-3-methoxy-1-(4-methoxybenzyl)-4-(piperazin-1-yl)-1H-pyrazolo[3,4-b]pyridine

Sources & evidence

ORD record
ord-10be2ee1ac2748b0a8557d1483128312
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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