Ethanol → Tert-butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

HRID 123264Notes

Reaction equation

HRID 123264 reaction equation
[CH3:27][CH2:28][OH:29].[Cl:14][c:15]1[n:16][cH:17][cH:18][c:19]([Cl:21])[n:20]1.[N:1]1([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]1.[Na+:26].[O-:22][C:23]([OH:24])=[O:25]>>[N:1]1([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:2][CH2:3][N:4]([c:19]2[cH:18][cH:17][n:16][c:15]([Cl:14])[n:20]2)[CH2:5][CH2:6]1

Participants

6

Reactant 5

HCID 702EthanolHCID 769Bicarbonate IonHCID 923Sodium ionHCID 775312,4-DichloropyrimidineHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 11197306Tert-butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-f95884744dcf4a55b63a9ca888ee6ae2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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