Hydrochloric Acid → 1-[2-(4-Amino-1-piperidinyl)ethyl]-5,7-difluoro-2(1H)-quinolinone

HRID 1232983Notes

Reaction equation

HRID 1232983 reaction equation
[CH2:35]1[O:36][CH2:37][CH2:38][O:39][CH2:40]1.[CH3:41][OH:42].[CH:31]([Cl:32])([Cl:33])[Cl:34].[ClH:30].[F:1][c:2]1[c:3]2[cH:4][cH:5][c:6](=[O:29])[n:7]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([NH:21][C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:19][CH2:20]3)[c:8]2[cH:9][c:10]([F:12])[cH:11]1>>[F:1][c:2]1[c:3]2[cH:4][cH:5][c:6](=[O:29])[n:7]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([NH2:21])[CH2:19][CH2:20]3)[c:8]2[cH:9][c:10]([F:12])[cH:11]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6212ChloroformHCID 312751,4-DioxaneHCID 86635322tert-Butyl {1-[2-(5,7-difluoro-2-oxoquinolin-1(2H)-yl)ethyl]piperidin-4-yl}carbamate

Product 1

HCID 667740021-[2-(4-Amino-1-piperidinyl)ethyl]-5,7-difluoro-2(1H)-quinolinone

Sources & evidence

ORD record
ord-192024e624894e6d9d1bfc29968a3492
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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