Dichloromethane → N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-4-(2-methylpyrazol-3-yl)furan-2-carboxamide

HRID 1233499Notes

Reaction equation

HRID 1233499 reaction equation
[Br:56][P+:57]([N:58]1[CH2:59][CH2:60][CH2:61][CH2:62]1)([N:63]1[CH2:64][CH2:65][CH2:66][CH2:67]1)[N:68]1[CH2:69][CH2:70][CH2:71][CH2:72]1.[CH3:1][n:2]1[n:3][cH:4][cH:5][c:6]1-[c:7]1[cH:8][c:9]([C:12](=[O:13])[OH:14])[o:10][cH:11]1.[CH:40]([N:41]([CH2:42][CH3:43])[CH:44]([CH3:45])[CH3:46])([CH3:47])[CH3:48].[Cl:73][CH2:74][Cl:75].[NH2:15][CH:16]([CH2:17][N:18]1[C:19](=[O:28])[c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[C:26]1=[O:27])[CH2:29][c:30]1[c:31]([C:36]([F:37])([F:38])[F:39])[cH:32][cH:33][cH:34][cH:35]1.[P-:49]([F:50])([F:51])([F:52])([F:53])([F:54])[F:55]>>[CH3:1][n:2]1[n:3][cH:4][cH:5][c:6]1-[c:7]1[cH:8][c:9]([C:12](=[O:14])[NH:15][CH:16]([CH2:17][N:18]2[C:19](=[O:28])[c:20]3[cH:21][cH:22][cH:23][cH:24][c:25]3[C:26]2=[O:27])[CH2:29][c:30]2[c:31]([C:36]([F:37])([F:38])[F:39])[cH:32][cH:33][cH:34][cH:35]2)[o:10][cH:11]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 2733180Bromotripyrrolidin-1-ylphosphoniumHCID 578267434-(1-methyl-1H-pyrazol-5-yl)-2-furancarboxylic acidHCID 1785107622-[2-amino-3-[2-(trifluoromethyl)phenyl]propyl]isoindole-1,3-dione

Product 1

HCID 76576406N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-4-(2-methylpyrazol-3-yl)furan-2-carboxamide

Sources & evidence

ORD record
ord-42b1cbfef197487bb60de979a6ed0040
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…