Acetonitrile → 5-bromo-2-(4-((6-(trifluoromethyl)pyridin-3-yl)methylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzonitrile
Reaction equation
[Br:23][c:24]1[cH:25][cH:26][c:27]([F:32])[c:28]([C:29]#[N:30])[cH:31]1.[CH3:42][C:43]#[N:44].[CH:33]([N:34]([CH2:35][CH3:36])[CH:37]([CH3:38])[CH3:39])([CH3:40])[CH3:41].[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]([CH2:9][NH:10][c:11]2[c:12]3[c:13]([n:14][cH:15][n:16]2)[CH2:17][CH2:18][NH:19][CH2:20]3)[cH:7][n:8]1)([F:21])[F:22]>>[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]([CH2:9][NH:10][c:11]2[c:12]3[c:13]([n:14][cH:15][n:16]2)[CH2:17][CH2:18][N:19]([c:27]2[cH:26][cH:25][c:24]([Br:23])[cH:31][c:28]2[C:29]#[N:30])[CH2:20]3)[cH:7][n:8]1)([F:21])[F:22]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-1d58ec49c40a46f5aa51c936df499186
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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