Water → 5-chloro-N-[1,3-dioxo-2-(4-piperidinyl)-2,3-dihydro-1H-isoindol-4-yl]-2-thiophenecarboxamide

HRID 1233788Notes

Reaction equation

HRID 1233788 reaction equation
[CH:42]([Cl:43])([Cl:44])[Cl:45].[Cl:9][c:10]1[cH:11][cH:12][c:13]([C:15](=[O:16])[NH:17][c:18]2[c:19]3[c:23]([cH:24][cH:25][cH:26]2)[C:22](=[O:27])[N:21]([CH:28]2[CH2:29][CH2:30][N:31]([C:34]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:40])[CH2:32][CH2:33]2)[C:20]3=[O:41])[s:14]1.[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[OH2:8]>>[Cl:9][c:10]1[cH:11][cH:12][c:13]([C:15](=[O:16])[NH:17][c:18]2[c:19]3[c:23]([cH:24][cH:25][cH:26]2)[C:22](=[O:27])[N:21]([CH:28]2[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]2)[C:20]3=[O:41])[s:14]1

Participants

5

Reactant 4

HCID 962WaterHCID 6212ChloroformHCID 6422Trifluoroacetic acidHCID 18440735tert-Butyl 4-(4-{[(5-chloro-2-thienyl)carbonyl]amino}-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)tetrahydro-1(2H)-pyridinecarboxylate

Product 1

HCID 120748935-chloro-N-[1,3-dioxo-2-(4-piperidinyl)-2,3-dihydro-1H-isoindol-4-yl]-2-thiophenecarboxamide

Sources & evidence

ORD record
ord-1580917e38224bfc8ef5c12d4d5f4a2d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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