Dichloromethane → 2-Chloro-6-(hexahydro-pyrrolo[3,4-c]pyrrol-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

HRID 1234122Notes

Reaction equation

HRID 1234122 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]2[CH2:11][N:12]([CH2:16][c:17]3[cH:18][c:19]4[n:20][c:21]([Cl:32])[n:22][c:23]([N:26]5[CH2:27][CH2:28][O:29][CH2:30][CH2:31]5)[c:24]4[s:25]3)[CH2:13][CH:14]2[CH2:15]1)([CH3:5])([CH3:6])[CH3:7].[Cl:40][CH2:41][Cl:42].[F:33][C:34]([F:35])([F:36])[C:37]([OH:38])=[O:39]>>[NH:8]1[CH2:9][CH:10]2[CH2:11][N:12]([CH2:16][c:17]3[cH:18][c:19]4[n:20][c:21]([Cl:32])[n:22][c:23]([N:26]5[CH2:27][CH2:28][O:29][CH2:30][CH2:31]5)[c:24]4[s:25]3)[CH2:13][CH:14]2[CH2:15]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 581170715-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester

Product 1

HCID 866501872-Chloro-6-(hexahydro-pyrrolo[3,4-c]pyrrol-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-2ba2f49d4e204628afc857d3ece1695b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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