N,N-Dimethylaniline → (4-Chloro-5-phenylthieno[2,3-d]pyrimidin-2-yl)acetic acid ethyl ester

HRID 1234353Notes

Reaction equation

HRID 1234353 reaction equation
[CH2:1]([CH3:2])[O:3][C:4]([CH2:5][c:6]1[nH:7][c:8](=[O:21])[c:9]2[c:10]([n:11]1)[s:12][cH:13][c:14]2-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)=[O:22].[CH3:28][N:29]([c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1)[CH3:36].[Cl:37][CH2:38][Cl:39].[P:23]([Cl:24])([Cl:25])([Cl:26])=[O:27]>>[CH2:1]([CH3:2])[O:3][C:4]([CH2:5][c:6]1[n:7][c:8]([Cl:25])[c:9]2[c:10]([n:11]1)[s:12][cH:13][c:14]2-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)=[O:22]

Participants

5

Reactant 4

HCID 949N,N-DimethylanilineHCID 6344DichloromethaneHCID 24813Phosphorus oxychlorideHCID 13591037(4-Oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)acetic acid ethyl ester

Product 1

HCID 11595162(4-Chloro-5-phenylthieno[2,3-d]pyrimidin-2-yl)acetic acid ethyl ester

Sources & evidence

ORD record
ord-500d26c9aacc4fd995636d53b5c41362
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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