Dichloromethane → 3,4-difluoro-2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-5-[[2-(methylamino)-2-oxoethoxy]iminomethyl]benzamide

HRID 1234463Notes

Reaction equation

HRID 1234463 reaction equation
[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH2:8]([Cl:9])[Cl:10].[F:11][c:12]1[c:13]([NH:28][c:29]2[c:30]([F:36])[cH:31][c:32]([I:35])[cH:33][cH:34]2)[c:14]([C:15](=[O:16])[NH:17][O:18][CH2:19][CH2:20][OH:21])[cH:22][c:23]([CH:26]=[O:27])[c:24]1[F:25].[NH2:1][O:2][CH2:3][C:4](=[O:5])[NH:6][CH3:7]>>[N:1]([O:2][CH2:3][C:4](=[O:5])[NH:6][CH3:7])=[CH:26][c:23]1[cH:22][c:14]([C:15](=[O:16])[NH:17][O:18][CH2:19][CH2:20][OH:21])[c:13]([NH:28][c:29]2[c:30]([F:36])[cH:31][c:32]([I:35])[cH:33][cH:34]2)[c:12]([F:11])[c:24]1[F:25]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 231323432-(Aminooxy)-n-methylacetamideHCID 231323883,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy)-benzamide

Product 1

HCID 740200123,4-difluoro-2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-5-[[2-(methylamino)-2-oxoethoxy]iminomethyl]benzamide

Sources & evidence

ORD record
ord-51319c73d8824414808383d42809b8b3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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