Tetrahydrofuran → (3,5-dimethoxy-phenyl)-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-methanone

HRID 1234523Notes

Reaction equation

HRID 1234523 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([cH:11][cH:12]1)[N:6]([CH3:10])[CH2:7][CH2:8][O:9]2.[CH2:13]([Li:14])[CH2:15][CH2:16][CH3:17].[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:18][O:19][c:20]1[cH:21][c:22]([C:23](=[O:24])[Cl:25])[cH:26][c:27]([O:29][CH3:30])[cH:28]1>>[c:2]1([C:23]([c:22]2[cH:21][c:20]([O:19][CH3:18])[cH:28][c:27]([O:29][CH3:30])[cH:26]2)=[O:24])[cH:3][c:4]2[c:5]([cH:11][cH:12]1)[N:6]([CH3:10])[CH2:7][CH2:8][O:9]2

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 870033,5-Dimethoxybenzoyl chlorideHCID 27764057-Bromo-3,4-dihydro-4-methyl-2H-1,4-benzoxazineHCID 178418339Butyllithium

Product 1

HCID 68939447(3,5-dimethoxy-phenyl)-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-methanone

Sources & evidence

ORD record
ord-4e6ba36f68c64cb1b6ffbde180e33b1f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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