Hydrochloric Acid → 3-Ethoxycarbonyl-7,9-difluoro-8-(4-hydroxy-1-piperazinyl)-1-methyl-4-oxo-1,4-dihydrobenzo [b][1,8]naphthyridine

HRID 1234605Notes

Reaction equation

HRID 1234605 reaction equation
[C:34](=[O:35])([O-:36])[O-:37].[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7](=[O:24])[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]2[n:14]([CH3:16])[cH:15]1)[c:17]([F:23])[c:18]([F:22])[c:19]([F:21])[cH:20]3.[ClH:25].[ClH:26].[K+:38].[K+:39].[OH:27][N:28]1[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7](=[O:24])[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]2[n:14]([CH3:16])[cH:15]1)[c:17]([F:23])[c:18]([N:31]1[CH2:30][CH2:29][N:28]([OH:27])[CH2:33][CH2:32]1)[c:19]([F:21])[cH:20]3

Participants

6

Reactant 5

HCID 313Hydrochloric Acid2×HCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 12463393Piperazin-1-olHCID 194236883-Ethoxycarbonyl-7,8,9-trifluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine

Product 1

HCID 545271483-Ethoxycarbonyl-7,9-difluoro-8-(4-hydroxy-1-piperazinyl)-1-methyl-4-oxo-1,4-dihydrobenzo [b][1,8]naphthyridine

Sources & evidence

ORD record
ord-15191dc557a344ad8b8d48bfd5fa44ed
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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