Toluene → Tert-butyl 4-(4-formylphenyl)piperazine-1-carboxylate

HRID 1235863Notes

Reaction equation

HRID 1235863 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[cH:6][cH:7]1.[CH3:21][CH2:22][CH2:23][CH2:24][Li:25].[CH3:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1.[O:26]=[CH:27][N:28]([CH3:29])[CH3:30]>>[c:2]1([CH:27]=[O:26])[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 6228DimethylformamideHCID 11824027Tert-butyl 4-(4-bromophenyl)piperazine-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 2795509Tert-butyl 4-(4-formylphenyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-d09ab87deec5457083edaa174e1b8ff0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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