1-(6-Bromopyridin-2-yl)-2,2,2-trifluoroethan-1-ol → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 1237163Notes

Reaction equation

HRID 1237163 reaction equation
[Br:22][c:23]1[cH:24][cH:25][cH:26][c:27]([CH:29]([C:30]([F:31])([F:32])[F:33])[OH:34])[n:28]1.[NH2:1][c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9]>>[NH:1]([c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9])[c:23]1[cH:24][cH:25][cH:26][c:27]([CH:29]([C:30]([F:31])([F:32])[F:33])[OH:34])[n:28]1

Participants

3

Reactant 2

HCID 583352521-(6-Bromopyridin-2-yl)-2,2,2-trifluoroethan-1-olHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595258035-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Sources & evidence

ORD record
ord-23489f76c2c34b3ab90e28e5af4f26bd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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