Dichloromethane → 4-(2,4-Dichlorophenyl)-4-piperidinol

HRID 1237240Notes

Reaction equation

HRID 1237240 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][C:11]([OH:14])([c:15]2[c:16]([Cl:22])[cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:30][CH2:31][Cl:32].[OH:23][C:24]([C:25]([F:26])([F:27])[F:28])=[O:29]>>[NH:8]1[CH2:9][CH2:10][C:11]([OH:14])([c:15]2[c:16]([Cl:22])[cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 575503704-(2,4-Dichloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 497606894-(2,4-Dichlorophenyl)-4-piperidinol

Sources & evidence

ORD record
ord-3bb0f9904e444c44a088b5e176b76cd9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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