Potassium Cation → Ethyl 2-chloro-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

HRID 1238330Notes

Reaction equation

HRID 1238330 reaction equation
[C:33](=[O:34])([O-:35])[O-:36].[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[O:7][CH2:8][CH3:9])[cH:10][cH:11][c:12]1[O:13][S:14]([C:15]([F:16])([F:17])[F:18])(=[O:19])=[O:20].[F:21][c:22]1[c:23]([B:30]([OH:31])[OH:32])[cH:24][c:25]([O:28][CH3:29])[cH:26][cH:27]1.[K+:37].[K+:38].[O:39]=[CH:40][N:41]([CH3:42])[CH3:43]>>[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[O:7][CH2:8][CH3:9])[cH:10][cH:11][c:12]1-[c:23]1[c:22]([F:21])[cH:27][cH:26][c:25]([O:28][CH3:29])[cH:24]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 41572112-Fluoro-5-methoxyphenylboronic acidHCID 57467588Ethyl 3-chloro-4-(trifluoromethylsulfonyloxy)benzoate

Product 1

HCID 57706474Ethyl 2-chloro-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

Sources & evidence

ORD record
ord-719795044df54f43965f68ff64170973
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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