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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 12385Generated: October 26, 2026

Acetic Anhydride → 1-Acetylindolin-2-one

https://huagongshe.com/reaction/12385

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AnhydrideHCID 7918—
ReactantOxindoleHCID 321710—
Product1-Acetylindolin-2-oneHCID 32371993.7%

Reaction Steps

Indoline-2-one (6.65 g, 50 mmol) and acetic anhydride (9 mL) were heated at reflux for 15 h. After cooling, the product was filtered and rinsed with Et2O to give 2a as solids after vacuum drying (8.2 g, yield: 93.7 %).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07728008B2
Source datasetuspto-grants-2010_06
ORD IDord-a7734ec7f6ab472a91dc21117afbdc06
Source noteuspto-grants-2010_06