Dichloromethane → (4-Azetidin-1-yl-piperidin-3-yl)-methanol

HRID 1238841Notes

Reaction equation

HRID 1238841 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]([CH2:18][OH:19])[CH:11]([N:14]2[CH2:15][CH2:16][CH2:17]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:27][CH2:28][Cl:29].[F:20][C:21]([F:22])([F:23])[C:24]([OH:25])=[O:26]>>[NH:8]1[CH2:9][CH:10]([CH2:18][OH:19])[CH:11]([N:14]2[CH2:15][CH2:16][CH2:17]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 668703894-Azetidin-1-yl-3-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 66870060(4-Azetidin-1-yl-piperidin-3-yl)-methanol

Sources & evidence

ORD record
ord-4c965137355d48e6b24360e997336f8a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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