Hydrogen iodide → 6-chloro-3-((4,6-difluoro-1-methyl-1H-indazol-5-yl)methyl)imidazo[1,2-b]pyridazine

HRID 1238911Notes

Reaction equation

HRID 1238911 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]2[n:6]([n:7]1)[c:8]([CH:11]([OH:12])[c:13]1[c:14]([F:24])[c:15]3[cH:16][n:17][n:18]([CH3:23])[c:19]3[cH:20][c:21]1[F:22])[cH:9][n:10]2.[Cl:29][c:30]1[cH:31][cH:32][c:33]2[n:34]([c:35]([CH:36]([c:37]3[c:38]([F:39])[c:40]4[c:41]([cH:42][c:43]3[F:44])[n:45]([CH3:46])[n:47][cH:48]4)[CH3:49])[cH:50][n:51]2)[n:52]1.[I:25].[PH2:26](=[O:27])[OH:28]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[n:6]([n:7]1)[c:8]([CH2:11][c:13]1[c:14]([F:24])[c:15]3[cH:16][n:17][n:18]([CH3:23])[c:19]3[cH:20][c:21]1[F:22])[cH:9][n:10]2

Participants

5

Reactant 4

HCID 24841Hydrogen iodideHCID 4124402Phosphinic AcidHCID 581475396-Chloro-3-[1-(4,6-difluoro-1-methyl-1H-indazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazineHCID 58190595(6-Chloroimidazo[1,2-b]pyridazin-3-yl)(4,6-difluoro-1-methyl-1H-indazol-5-yl)methanol

Product 1

HCID 581475346-chloro-3-((4,6-difluoro-1-methyl-1H-indazol-5-yl)methyl)imidazo[1,2-b]pyridazine

Sources & evidence

ORD record
ord-db5fb6ea1b224311b58289768fb8746b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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