Imidazole → 2-Bromo-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-chloro-phenylamine

HRID 1239277Notes

Reaction equation

HRID 1239277 reaction equation
[C:13]([CH3:14])([CH3:15])([CH3:16])[Si:17]([CH3:18])([CH3:19])[Cl:20].[NH2:1][c:2]1[c:3]([Br:12])[cH:4][c:5]([Cl:11])[c:6]([CH:8]([CH3:9])[OH:10])[cH:7]1.[O:27]=[CH:28][N:29]([CH3:30])[CH3:31].[OH2:26].[nH:21]1[cH:22][cH:23][n:24][cH:25]1>>[NH2:1][c:2]1[c:3]([Br:12])[cH:4][c:5]([Cl:11])[c:6]([CH:8]([CH3:9])[O:10][Si:17]([C:13]([CH3:14])([CH3:15])[CH3:16])([CH3:18])[CH3:19])[cH:7]1

Participants

6

Reactant 5

HCID 795ImidazoleHCID 962WaterHCID 6228DimethylformamideHCID 28928tert-Butyldimethylsilyl chlorideHCID 593778031-(5-Amino-4-bromo-2-chloro-phenyl)-ethanol

Product 1

HCID 593778892-Bromo-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-chloro-phenylamine

Sources & evidence

ORD record
ord-913c5de15e0f4adda9e658cb330dbc43
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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