反应详情

温度

-78 °C

To a solution of oxalyl chloride (490 μL, 5.6 mmol) in DCM (10 mL) at −78° C. was added DMSO (796 μL, 11.2 mmol) dropwise followed by the addition of a solution of 20b (943 mg, 5.6 mmol) in DCM (2 mL). The mixture was stirred at −78° C. for 30 min and TEA (3.6 mL, 25.5 mmol) was added. The reaction was stirred at −78° C. for 5 min, warmed to rt and stirred at rt for 30 min. The reaction was quenched with water and extracted with DCM. The organic layers were combined and washed with water, dried over magnesium sulfate to give 20c as a yellow semi-solid (880 mg).

1. stirringThe reaction was stirred at −78° C. for 5 min
2. temperaturewarmed to rt
3. stirringstirred at rt for 30 min
4. customThe reaction was quenched with water
5. extractionextracted with DCM
6. washwashed with water
7. dry with materialdried over magnesium sulfate