Tetrahydrofuran → N-(2-bromo-4,5-dimethoxyphenyl)-2-(4-fluorophenyl)-4-oxo-2,3-dihydropyridine-1-carboxamide

HRID 1240250Notes

Reaction equation

HRID 1240250 reaction equation
[Br:20][c:21]1[c:22]([N:31]=[C:32]=[O:33])[cH:23][c:24]([O:29][CH3:30])[c:25]([O:27][CH3:28])[cH:26]1.[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[CH3:15][CH2:16][CH2:17][CH2:18][Li:19].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[NH:9][CH:10]=[CH:11][C:12](=[O:14])[CH2:13]2)[cH:6][cH:7]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[N:9]([C:32]([NH:31][c:22]3[c:21]([Br:20])[cH:26][c:25]([O:27][CH3:28])[c:24]([O:29][CH3:30])[cH:23]3)=[O:33])[CH:10]=[CH:11][C:12](=[O:14])[CH2:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 582002611-Bromo-2-isocyanato-4,5-dimethoxybenzeneHCID 669062792-(4-fluorophenyl)-2,3-dihydro-1H-pyridin-4-oneHCID 178418339Butyllithium

Product 1

HCID 75214946N-(2-bromo-4,5-dimethoxyphenyl)-2-(4-fluorophenyl)-4-oxo-2,3-dihydropyridine-1-carboxamide

Sources & evidence

ORD record
ord-ed611d7ad1b642db9b145cee55e0abea
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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