Dichloromethane → N-(3-fluoro-4-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)phenyl)-2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide

HRID 1240300Notes

Reaction equation

[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][n:8]2[n:9][c:10]([N:42]3[CH2:43][CH:44]4[CH:45]([CH2:46]3)[CH2:47][N:48]([C:50]([O:51][C:52]([CH3:53])([CH3:54])[CH3:55])=[O:56])[CH2:49]4)[c:11]3[c:12]2[n:13][cH:14][cH:15][c:16]3[O:17][c:18]2[c:19]([F:41])[cH:20][c:21]([NH:24][C:25](=[O:26])[c:27]3[cH:28][cH:29][n:30][n:31](-[c:34]4[cH:35][cH:36][c:37]([F:40])[cH:38][cH:39]4)[c:32]3=[O:33])[cH:22][cH:23]2)[cH:57][cH:58]1.[Cl:66][CH2:67][Cl:68].[F:59][C:60]([F:61])([F:62])[C:63]([OH:64])=[O:65]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][n:8]2[n:9][c:10]([N:42]3[CH2:43][CH:44]4[CH:45]([CH2:46]3)[CH2:47][NH:48][CH2:49]4)[c:11]3[c:12]2[n:13][cH:14][cH:15][c:16]3[O:17][c:18]2[c:19]([F:41])[cH:20][c:21]([NH:24][C:25](=[O:26])[c:27]3[cH:28][cH:29][n:30][n:31](-[c:34]4[cH:35][cH:36][c:37]([F:40])[cH:38][cH:39]4)[c:32]3=[O:33])[cH:22][cH:23]2)[cH:57][cH:58]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 68512270tert-butyl 5-(1-(4-methoxybenzyl)-4-(2-fluoro-4-(1-(4-fluorophenyl)-6-oxo-1,6-dihydropyridazine-5-carboxamido)phenoxy)-1H-pyrazolo[3,4-b]pyridin-3-yl)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Product 1

HCID 68512954N-(3-fluoro-4-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)phenyl)-2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide

Sources & evidence

ORD record: ord-370d3dd022dc434fbdf2a341ca6cd265
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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