Dimethyl Sulfoxide → trans-N1-(5-chloro-4-(5-ethyl-6-((tetrahydro-2H-pyran-4-yl)methyl)aminopyrazin-2-yl)pyridin-2-yl)cyclohexane-1,4-diamine

HRID 1240576Notes

Reaction equation

HRID 1240576 reaction equation
[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[CH3:40][S:41]([CH3:42])=[O:43].[Cl:1][c:2]1[c:3](-[c:9]2[cH:10][n:11][c:12]([CH2:23][CH3:24])[c:13]([NH:15][CH2:16][CH:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)[n:14]2)[cH:4][c:5]([F:8])[n:6][cH:7]1.[NH2:25][CH:26]1[CH2:27][CH2:28][CH:29]([NH2:32])[CH2:30][CH2:31]1>>[Cl:1][c:2]1[c:3](-[c:9]2[cH:10][n:11][c:12]([CH2:23][CH3:24])[c:13]([NH:15][CH2:16][CH:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)[n:14]2)[cH:4][c:5]([NH:25][CH:26]2[CH2:27][CH2:28][CH:29]([NH2:32])[CH2:30][CH2:31]2)[n:6][cH:7]1

Participants

5

Reactant 4

HCID 679Dimethyl SulfoxideHCID 8471TriethylamineHCID 183741,4-DiaminocyclohexaneHCID 669371206-(5-chloro-2-fluoropyridin-4-yl)-3-ethyl-N-((tetrahydro-2H-pyran-4-yl)methyl)pyrazine-2-amine

Product 1

HCID 68405477trans-N1-(5-chloro-4-(5-ethyl-6-((tetrahydro-2H-pyran-4-yl)methyl)aminopyrazin-2-yl)pyridin-2-yl)cyclohexane-1,4-diamine

Sources & evidence

ORD record
ord-091fbd3e909d434bb10ffbba14205c96
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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