HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 12406Generated: October 26, 2026
Dimethylformamide → t-butyl (1S)-2-(3-fluorophenoxy)-1-methylethylcarbamate
https://huagongshe.com/reaction/12406
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 3-Fluorophenol | HCID 9743 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | t-butyl (1S)-2-chloro-1-methylethylcarbamate | HCID 86761117 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | t-butyl (1S)-2-(3-fluorophenoxy)-1-methylethylcarbamate | HCID 86761118 | — |
Reaction Steps
To the compound (500 mg) obtained in Step 3 were added 3-fluorophenol (84 μl), potassium carbonate (250 mg) and DMF (2 ml), and the mixture was stirred overnight at 95° C. The reaction mixture was diluted with ethyl acetate. After washing with water, the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound as a crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07728005B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-b140c6747a1a44558eefb386d2991521 |
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| Source note | uspto-grants-2010_06 |
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