1,2-Dibromoethane → 4-(2-chloro-9-methyl-6-morpholin-4-yl-9H-purin-8-yl)piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[Br:1][CH2:2][CH2:3][Br:4].[C:5]([CH3:6])([CH3:7])([CH3:8])[O:9][C:10](=[O:11])[N:12]1[CH2:13][CH2:14][CH:15]([I:18])[CH2:16][CH2:17]1.[Cl:19][c:20]1[n:21][c:22]([N:31]2[CH2:32][CH2:33][O:34][CH2:35][CH2:36]2)[c:23]2[n:24][c:25]([I:30])[n:26]([CH3:29])[c:27]2[n:28]1.[Cu:38][I:39].[Zn:37]>>[C:5]([CH3:6])([CH3:7])([CH3:8])[O:9][C:10](=[O:11])[N:12]1[CH2:13][CH2:14][CH:15]([c:25]2[n:24][c:23]3[c:22]([N:31]4[CH2:32][CH2:33][O:34][CH2:35][CH2:36]4)[n:21][c:20]([Cl:19])[n:28][c:27]3[n:26]2[CH3:29])[CH2:16][CH2:17]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-dc59869d437d48d8b8bef8877ffc7a18
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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