反应详情

温度

85 °C

(R)-7-Diethylaminocarbonylmethyloxy-3-(2-phthalimidopropyl)indole 10.27 g was suspended in 100 ml of ethanol, and 2.5 ml of hydrazine monohydrate was added thereto. The suspension was heated to reflux in an oil bath of 85° C. For 3 hours. After cooling down, the resulting deposited insoluble materials were filtered off, and the filtrate was concentrated under reduced pressure. Ethyl acetate and a sodium hydroxide aqueous solution were added to the residue and distributed in liquid-liquid, and the organic layer was further washed with a sodium hydroxide aqueous solution and dried. The solution was evaporated under reduced pressure. The resulting residue was slowly crystallized, and dried under reduced pressure, whereby 6.90 g of the title compound was obtained in the form of a pale brownish white substance.

1. temperatureThe suspension was heated
2. temperatureAfter cooling down
3. filtrationwere filtered off
4. concentrationthe filtrate was concentrated under reduced pressure
5. additionEthyl acetate and a sodium hydroxide aqueous solution were added to the residue
6. washthe organic layer was further washed with a sodium hydroxide aqueous solution
7. customdried
8. customThe solution was evaporated under reduced pressure
9. customThe resulting residue was slowly crystallized
10. customdried under reduced pressure