HCID 178473680, compound → HCID 178507648, compound

HRID 1241339Notes

Reaction equation

HRID 1241339 reaction equation
C([O:3][P:4]([C:9]([C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1)([O:12]CC)[PH2:10]=[O:11])(=[O:8])[O:5]CC)C>Cl>[NH2:21][C:18]1[CH:17]=[CH:16][C:15]([C:9]([P:4](=[O:3])([OH:5])[OH:8])([OH:12])[PH2:10]=[O:11])=[CH:20][CH:19]=1

Participants

3

Reactant 1

HCID 178473680HCID 178473680, compound

Product 1

HCID 178507648HCID 178507648, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of [(4-Amino-phenyl)-ethoxy-phosphinoylmethyl]-phosphonic acid diethyl ester (2.78 g, 8.29 mmol) in 250 mL of conc. HCl was heated at reflux (apparatus equipped with a NaOH trap) for 5 h. Concentrated solution via distillation to provide a sticky yellow-white solid, which was used without purification in the next step: m/z 252 (M+H).

Workup

  1. temperatureat reflux
  2. custom(apparatus equipped with a NaOH trap) for 5 h
  3. distillationConcentrated solution via distillation
  4. customto provide a sticky yellow-white solid, which
  5. customwas used without purification in the next step

Sources & evidence

ORD record
ord-9bc181b735f841fcabfabd8a92f69fec
Source dataset
uspto-grants-2006_10
Patent number
US07115589B2

Reaction notes

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