反应详情

A solution of [(4-Amino-phenyl)-ethoxy-phosphinoylmethyl]-phosphonic acid diethyl ester (2.78 g, 8.29 mmol) in 250 mL of conc. HCl was heated at reflux (apparatus equipped with a NaOH trap) for 5 h. Concentrated solution via distillation to provide a sticky yellow-white solid, which was used without purification in the next step: m/z 252 (M+H).

1. temperatureat reflux
2. custom(apparatus equipped with a NaOH trap) for 5 h
3. distillationConcentrated solution via distillation
4. customto provide a sticky yellow-white solid, which
5. customwas used without purification in the next step