Diisopropylethylamine → HCID 21934631, compound

HRID 1241387Notes

Reaction equation

HRID 1241387 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.C(N(C(C)C)CC)(C)C.[O:18]=[C:19]([N:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1)[CH2:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>C(O)CCC>[O:18]=[C:19]([N:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1)[CH2:20][N:21]1[CH2:26][CH2:25][N:24]([C:2]2[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=2)[CH2:23][CH2:22]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 1006141-((Pyrrolidine-1-carbonyl)methyl)piperazineHCID 2380124-Amino-6-chloropyrimidine

Product 1

HCID 21934631HCID 21934631, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
150 °C

Procedure

6-Chloropyrimidin-4-amine 7-2 (0.50 g, 3.86 mmol) and diisopropylethylamine (0.499 g, 3.86 mmol) were suspended in n-butanol and then 1-(2-oxo-2-pyrrolidin-1-ylethyl)piperazine 17-1 (0.762 g, 3.86 mmol) was added. The reaction was stirred at 150° C. for 18 hours and then the product was filtered off, washed with n-butanol and ethyl ether and air dried. 1H-NMR (CD3OD): 7.96 ppm (s, 1H); 5.72 ppm (s, 1H); 3.55 ppm (m, 6H); 3.44 ppm (t, 2H); 3.24 ppm (s, 2H); 2.60 ppm (t, 2H); 1.98 ppm (m, 2H); 1.88 ppm (m, 2H).

Workup

  1. filtrationthe product was filtered off
  2. washwashed with n-butanol and ethyl ether and air
  3. customdried

Sources & evidence

ORD record
ord-2c7d9c659ecb4f3391c2742d44cf63ff
Source dataset
uspto-grants-2006_10
Patent number
US07115597B2

Reaction notes

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