6-Chloro-2-methylpyrimidin-4-amine → HCID 21934648, compound

HRID 1241389Notes

Reaction equation

HRID 1241389 reaction equation
[CH3:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([NH2:9])[N:3]=1.[N:10]1([CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[CH3:1][C:2]1[N:3]=[C:4]([NH2:9])[CH:5]=[C:6]([N:13]2[CH2:12][CH2:11][N:10]([CH2:16][CH2:17][N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[CH2:15][CH2:14]2)[N:7]=1

Participants

3

Reactant 2

HCID 2867546-Chloro-2-methylpyrimidin-4-amineHCID 27346404-(2-Piperazin-1-yl-ethyl)-morpholine

Product 1

HCID 21934648HCID 21934648, compound

Procedure

210 mg (1.47 mmol) of 2-methyl-4-chloro-6-aminopyrimidine 20-1 and 294 mg (1.47 mmol) of 4-(2-piperazin-1-ylethyl)morpholine 7-3 were used to obtain the desired product 20-2 as a yellow oil/solid. MS M+1=307. H1 NMR (CDCl3): 2.37(s, 3H), 2.53(br m, 4H), 2.57(br m, 4H), 3.57(m, 4H), 3.73(m, 4H), 4.52(br s, 2H), 5.41(s, 1H).

Sources & evidence

ORD record
ord-887af24374724aa1b81d9a5863d0b9c7
Source dataset
uspto-grants-2006_10
Patent number
US07115597B2

Reaction notes

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