Diisopropylethylamine → HCID 21934699, compound

HRID 1241412Notes

Reaction equation

HRID 1241412 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.[O:9]=[C:10]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)[CH2:11][N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.CCN(C(C)C)C(C)C>>[N:12]1([CH2:11][C:10]([N:18]2[CH2:19][CH2:20][N:21]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=3)[CH2:22][CH2:23]2)=[O:9])[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 2380124-Amino-6-chloropyrimidineHCID 162276322-(4-morpholinyl)-1-(1-piperazinyl)Ethanone

Product 1

HCID 21934699HCID 21934699, compound

Procedure

7-2 (0.22 g, 1.76 mmol), 42-2 (0.37 g, 1.76 mmol) and DIEA (0.23 g, 1.76 mmol) were reacted to afford 42-3, which was purified on a silica column. 1H-NMR(CD3OD): 8.00(s, 1H); 5.75(s, 1H); 3.70(m, 6H); 3.65(m, 4H); 3.56(m, 2H); 3.30(s, 2H); 2.54(br s, 4H).

Workup

  1. customto afford 42-3, which
  2. customwas purified on a silica column

Sources & evidence

ORD record
ord-c74a8651542040c28bfae309fa11cf5f
Source dataset
uspto-grants-2006_10
Patent number
US07115597B2

Reaction notes

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