反应详情

2.02 (8.6 mmol, 1 equiv.) 3-bromobenzenecarboximidamide hydrochloride are suspended in 50 ml of ethanol and 1.47 g (10.2 mmol, 1.2 equiv.) hydrazine hydrate are added. After stirring at room temperature for 1 hour, 2.59 g (13 mmol, 1.5 equiv) of the compound of Example 2A, dissolved in 10 ml of ethanol, are added. The reaction mixture is stirred at 80° C. (bath temperature) for 4 hours and then at room temperature over night. The mixture is evaporated to dryness in vacuo and the product is purified by chromatography (flash or column chromatography or preparative HPLC).

1. additionare added
2. stirringThe reaction mixture is stirred at 80° C. (bath temperature) for 4 hours
3. waitat room temperature over night
4. customThe mixture is evaporated to dryness in vacuo
5. customthe product is purified by chromatography (flash or column chromatography or preparative HPLC)